N-Methyl-N-Nitrosourea–Induced Acute Alteration of Retinal Function and Morphology in Monkeys
نویسندگان
چکیده
منابع مشابه
N-Methyl-N-Nitrosourea-Induced Acute Alteration of Retinal Function and Morphology in Monkeys.
PURPOSE The purpose of this study was to investigate both functional and morphologic alteration of the retina acutely induced by N-methyl-N-nitrosourea (MNU) in monkeys. METHODS The MNU was administered intravenously at a single dose of 40 mg/kg to six cynomolgus monkeys, and standard full-field electroretinograms (ERGs) were recorded 1, 3, and 7 days after dosing. In addition, the rod and co...
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15 صفحه اولInfluence of Methyl and Isopropyl N-methyl Antranilates on Carbon Tetrachloride-induced Changes in Rat Liver Morphology and Function
The aim of the present study was to examine potential protective effects of methyl N-methylanthranilate (M) and isopropyl N-methylanthranilate (I) in a rat model of acute intoxication with carbon tetrachloride (CCl4) by tracking the changes in liver morphology and function. Serum transaminase and bilirubin were significantly elevated in animals treated with CCl4 alone. A pretreatment with M and...
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ژورنال
عنوان ژورنال: Investigative Opthalmology & Visual Science
سال: 2015
ISSN: 1552-5783
DOI: 10.1167/iovs.15-16929